Wednesday, April 24, 2024

Recent Scientific Research on Psychedelics


Recent Research by Substance and Year

PEx has collected a list of some of the most recent and cutting-edge peer-reviewed scholarly research into psychedelics. Substances are listed in alphabetical order. We are constantly updating this page. Spot an error or have a new study to add? Let us know!

Ayahuasca and Mental Health:  Depression, Anxiety, Suicidality, Addiction, Eating Disorders, Personality Disorders, Grief


A placebo-controlled study of the effects of ayahuasca, set and setting on mental health of participants in ayahuasca group retreats


Effects of ayahuasca on mental health and quality of life in naïve users: A longitudinal and cross-sectional study combination

Rapid and sustained decreases in suicidality following a single dose of ayahuasca among individuals with recurrent major depressive disorder: results from an open-label trial

Therapeutic potential of ayahuasca in grief: a prospective, observational study

Modulatory effects of ayahuasca on personality structure in a traditional framework

Personality Traits in Former Spanish Substance Users Recovered with Ayahuasca

Pilot Evaluation of a Residential Drug Addiction Treatment Combining Traditional Amazonian Medicine, Ayahuasca and Psychotherapy on Depression and Anxiety

The ritual use of ayahuasca during treatment of severe physical illnesses: a qualitative study


Ayahuasca: Psychological and Physiologic Effects, Pharmacology and Potential Uses in Addiction and Mental Illness

Acute effects of ayahuasca in a juvenile non-human primate model of depression

Ayahuasca improves emotion dysregulation in a community sample and in individuals with borderline-like traits


Rapid antidepressant effects of the psychedelic ayahuasca in treatment-resistant depression: a randomized placebo-controlled trial

Cortisol Modulation by Ayahuasca in Patients With Treatment Resistant Depression and Healthy Controls

Four Weekly Ayahuasca Sessions Lead to Increases in “Acceptance” Capacities: A Comparison Study With a Standard 8-Week Mindfulness Training Program

Long-term effects of ayahuasca in patients with recurrent depression: a 5-year qualitative follow-up

Is Ayahuasca an Option for the Treatment of Crack Cocaine Dependence?

Sub-acute and long-term effects of ayahuasca on affect and cognitive thinking style and their association with ego dissolution


Nourishing the Spirit: Exploratory Research on Ayahuasca Experiences along the Continuum of Recovery from Eating Disorders

Assessing the Psychedelic “After-Glow” in Ayahuasca Users: Post-Acute Neurometabolic and Functional Connectivity Changes Are Associated with Enhanced Mindfulness Capacities

Potential Use of Ayahuasca in Grief Therapy

Ayahuasca and Physical Health: Neurogenesis, Anti-Inflammation, Detoxification


N,N-dimethyltryptamine compound found in the hallucinogenic tea ayahuasca, regulates adult neurogenesis in vitro and in vivo

Subacute effects of the psychedelic ayahuasca on the salience and default mode networks

Anti-inflammatory activity of ayahuasca: therapeutical implications in neurological and psychiatric diseases


Purging and the body in the therapeutic use of ayahuasca

Ayahuasca, an ancient substance with traditional and contemporary use in neuropsychiatry and neuroscience

Ayahuasca: Uses, Phytochemical and Biological Activities

Iboga and Mental Health: Addiction


Novel treatment of opioid use disorder using ibogaine and iboga in two adults


Ibogaine therapy for addiction: Consumer views from online fora


Biosynthesis of an Anti-Addiction Agent from the Iboga Plant

Ibogaine and Subjective Experience: Transformative States and Psychopharmacotherapy in the Treatment of Opioid Use Disorder


Ibogaine treatment outcomes for opioid dependence from a twelve-month follow-up observational study

Ibogaine Detoxification Transitions Opioid and Cocaine Abusers Between Dependence and Abstinence: Clinical Observations and Treatment Outcomes

Ibogaine as a treatment for substance misuse: Potential benefits and practical dangers

Breaking the cycle of opioid use disorder with Ibogaine

Understanding the Healing Potential of Ibogaine through a Comparative and Interpretive Phenomenology of the Visionary Experience

Changes in Withdrawal and Craving Scores in Participants Undergoing Opioid Detoxification Utilizing Ibogaine

LSD: Neuroscience and Consciousness


Lysergic acid diethylamide (LSD) promotes social behavior through mTORC1 in the excitatory neurotransmission


Effective connectivity changes in LSD-induced altered states of consciousness in humans


Changes in global and thalamic brain connectivity in LSD-induced altered states of consciousness are attributable to the 5-HT2A receptor

Long-lasting subjective effects of LSD in normal subjects


Alterations of consciousness and mystical-type experiences after acute LSD in humans

MDMA and Mental Health: PTSD, Therapy


Long-term follow-up outcomes of MDMA-assisted psychotherapy for treatment of PTSD: a longitudinal pooled analysis of six phase 2 trials


MDMA-assisted psychotherapy for treatment of PTSD: study design and rationale for phase 3 trials based on pooled analysis of six phase 2 randomized controlled trials

Breakthrough for Trauma Treatment: Safety and Efficacy of MDMA-Assisted Psychotherapy Compared to Paroxetine and Sertraline

Perceived Benefits of MDMA-Assisted Psychotherapy beyond Symptom Reduction: Qualitative Follow-Up Study of a Clinical Trial for Individuals with Treatment-Resistant PTSD


Progress and promise for the MDMA drug development program


MDMA and PTSD treatment: “PTSD: From novel pathophysiology to innovative therapeutics”

Potential Psychiatric Uses for MDMA

Therapeutic effect of increased openness: Investigating mechanism of action in MDMA-assisted psychotherapy

Psilocybin and Mental Health: Depression, Anxiety, End-of-Life Acceptance


What is the clinical evidence on psilocybin for the treatment of psychiatric disorders? A systematic review


Effects of Psilocybin-Assisted Therapy on Major Depressive Disorder

Psilocybin as a New Approach to Treat Depression and Anxiety in the Context of Life-Threatening Diseases—A Systematic Review and Meta-Analysis of Clinical Trials

Depression, Mindfulness, and Psilocybin: Possible Complementary Effects of Mindfulness Meditation and Psilocybin in the Treatment of Depression. A Review

Psilocybin-assisted therapy of major depressive disorder using Acceptance and Commitment Therapy as a therapeutic frame

Psilocybin occasioned mystical‐type experiences

Psilocybin and LSD in the Treatment of Depression and Anxiety


Psilocybin with psychological support for treatment-resistant depression: six-month follow-up

Quality of Acute Psychedelic Experience Predicts Therapeutic Efficacy of Psilocybin for Treatment-Resistant Depression

Increased amygdala responses to emotional faces after psilocybin for treatment-resistant depression

Increased nature relatedness and decreased authoritarian political views after psilocybin for treatment-resistant depression


Psilocybin for treatment-resistant depression: fMRI-measured brain mechanisms

Patients’ Accounts of Increased “Connectedness” and “Acceptance” After Psilocybin for Treatment-Resistant Depression

Read more

Local News