What is San Pedro?
San Pedro, also known as huachuma, is a large, thin, column-shaped cactus that grows in the Andes mountain range, in South America. The active psychedelic ingredient in San Pedro is mescaline.
Traditionally, San Pedro is either consumed alone or in ceremony with other plants in a traditional brew called cimora. When taken alone, San Pedro can be swallowed as a powder, or mixed with water to create a tea.
What is San Pedro like?
After consuming San Pedro, psychedelic effects begin within 15-40 minutes. Participants may feel tingling, as well as some nausea or dizziness at the start of the journey. The peak experience often includes strong, colorful visual effects, synesthesia, distortions of spatial awareness, and out-of-body experiences. It can take up to three hours to reach the peak of the session, and effects are felt for up to 10 hours in total. San Pedro is an empathogen, like MDMA, meaning that it creates a strong sense of empathy, emotional connection, wonder, and awe.
A Brief History of San Pedro
Various indigenous people groups in South America, and particularly in Peru, have used San Pedro in religious and spiritual ceremonies for at least 3,000 years (Rudgley, 1998). One of the earliest visual representations of the San Pedro cactus is a carving from the Chavin culture (c.1400-400 BC), located in an ancient temple in the Peruvian highlands. The carving shows a mythological creature holding San Pedro.When European missionaries arrived in the Americas, they perceived San Pedro negatively and discouraged its use. The plant’s status as a sacred entheogen has not wavered, however, in spite of persecution. In recent years there has been a resurgence in its popularity, and there are currently many retreat centers and organizations that offer San Pedro ceremonies in South America.
San Pedro Science
The active psychoactive component in San Pedro (huachuma) is naturally-occurring mescaline. Mescaline has a phenethylamine structure. As a phenethylamine, it is similar to MDMA, but falls in a different class from tryptamines, such as LSD, DMT, and psilocybin.
Like most psychedelics, however, mescaline acts upon the brain’s serotonergic system, particularly serotonin 2A receptors. In addition to interacting with serotonin receptors, mescaline activates the brain’s dopaminergic system and binds with dopamine receptors.
In comparison with other psychedelics, studies on the therapeutic potential of San Pedro remain limited. There are many anecdotal accounts of life-changing experiences with San Pedro, but little formal research has been conducted at this point.
There is some evidence, however, that mescaline, the active ingredient in San Pedro, increases activity and blood flow in the prefrontal cortex of the brain. Lower levels of activity in the prefrontal cortex are linked to anxiety and depression, suggesting that mescaline may be useful in treating certain mental disorders, particularly mood disorders.
Mescaline’s interactions with both serotonin and dopamine receptors imply that it can help to boost mood and treat depression. In traditional Mesoamerican cultures, plant-based cacti, like San Pedro, was used to treat depression (Horgan, 2009). Its pharmacological similarity to MDMA also suggests a possible use in the treatment of PTSD.